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MMM-DNA120 and MMM-DNA170 DNA Assembly Instructions

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MMM-DNA1000 and MMM-DNA1700 DNA Assembly Instructions


Assemble 5 (DNA-1000) or 8 (DNA-1700) Adenine and Thymine Base Pairs as follows:


You can configure the all gray bond version.
Thymine Adenine DNA double helix Base pair














Or the clear/gray bond version to distinguish the double bonds present in the base pairs.
Thymine Adenine DNA Double helix molecular model of a base pairs














Note:  The longer 30 mm bonds representing the weaker hydrogen bonding between the thymine and adenine base pairs.  You will use the short 20 mm bonds for all remaining bonds regardless of color chosen.

Assemble 5 (DNA-1000) or 9 (DNA-1700) Cytosine and Guanine Base Pairs as follows:

You can configure the all grey bond version.
Cytosine Guanine base pair DNA double helix molecular model













Or the clear/gray bond version to distinguish the double bonds.

 

 

 

 

 





Note: The longer 30 mm bonds representing the weaker hydrogen bonding between the thymine and adenine base pairs.  All other bond lengths are 20 mm regardless of color chosen.

Assemble 18 (DNA-1000) or 32 (DNA-1700) of the Phosphate-C6 carbon back bone units as follows:
















Note: All gray 20 mm bonds used.  The carbon tetrahedral is C6 of the deoxyribose sugar units.

Assemble 20 (DNA-1000) or 34 (DNA-1700) of the deoxyribose ring structures:

10 (DNA-1000) -17 (DNA-1700) will look like the following and be used for the right side of your model when assembling.
deoxyribose sugar dna double helix molecular model














Note: All 20 mm grey bonds used.  The orientation of the left molecule in the image above is how it will attach to the bases when assembled.  The right model in the image above is the molecule turned 180 degrees or fliped over.

Another view of the above shown below.  Same orientation maintained.
deoxyribose dna double helix back bone














Note: All 20 mm grey bonds used.  The orientation of the left molecule in the image above is how it will attach to the bases on the left side when attached to the bases.  The right model in the image above is the molecule turned 180 degrees or flipped over.

Below shows how the right model orientation will eventually be attached to your DNA bases.  Once you have assembled the correct amount for your kit set them aside.





























Now assemble the 10 (DNA-1000) -17 (DNA-1700) will look like the following and be used for the left side of your model when assembling it.















Note: All 20 mm grey bonds used.  The orientation of the left molecule in the image above is how it will attach to the bases when assembled.  The right model in the image above is the molecule turned 180 degrees or flipped over.

Another view of the above shown below.  Same orientation maintained.















Below shows how the right model orientation will eventually be attached to your DNA bases.  Once you have assembled the correct amount for your kit set them aside.
deoxyribose sugar for dna double helix molecular model


























Now assemble your DNA model on your pre-assembled stand. 

The base sequence shown in the final structure(s) (Left to Right below = Botton to Top of model) is as follows:

MMM-DNA1700
Bottom                                       Top
   3' TCGATTGAGCTCTAGCG 5'
   5' AGCTAACTCGAGATCGC 3'

Top
5'   3'
G - C
C - G
G - C
A - T
T - A
C - G
T - A
C - G
G - C
A - T
G - C
T - A
T - A
A - T
G - C
C - G
T - A
3'   5'
Bottom (or stand)
 

MMM-DNA1000

   3' TTGAGCTCTAGCG 5'
   5' AACTCGAGATCGC 3'

Top
5'   3'
C - G
G - C
A - T
G - C
T - A
T - A
A - T
G - C
C - G
T - A
3'   5'
Bottom (or stand)

Now place your DNA base pair from above over the threaded rod on to the shelf and secure it with the zip ties (note that the individual shelf is shown for demonstration purposes).  The base pair should sit on the shelf as noted.  If there is overhang on either side or the drilled holes for the zip ties do not align to secure the bond on the ringed structures you have the orientation wrong.
DNA double helix adenine thymine base pair on shelf molecular model kit
























Now orient all the shelves so that all open R' spots are facing you and the zip ties are away from you as shown below.  This is the opposite of the above pic as the R' are facing away from you and the zip ties towards you.  Note how the bases sit equal on the shelves.  The picture shows 10 base pairs from the above noted diagram.
DNA atomic double helix molecular model base pairs
























Begin placing deoxyribose ring structures on your right as shown.  Work all the way up the molecule maintaining the same orientation.  These are the first ringed structures you assembled, labeled and set aside from above.
DNA double helix deoxyribose ring
























Repeat the same on the left with the following orientation.  Note how the hydrogen on the C1 carbon is up on the right and down on the left.
DNA double helix deoxyribose sugar back bone molecular model
























Your Model should look like the following image below with the sugar rings running up both sides in the correct orientation.
DNA double helix deoxyribose sugar placement
























Begin attaching your sugar structures together on the right side of your model by attaching the oxygen (from the back bone units already assembled) to the open C3 carbon on the lower ring and the tetrahedral carbon (C6) to the upper open C5 carbon on the upper sugar unit.  Work your way up the right side repeating this sequence.  You will need to adjust the shelving and begin a counter clockwise rotation.  You are now assembling the 5' to 3' chain (see above diagram).
DNA double helix back bone





 


















Now complete the left side as shown below.  You will be attaching your C6 carbon on to the open C5 atom.  You will then attach your open oxygen (from the back bone units already assembled) to the open C3 spot on the above ring structure.  Repeat this action all the way to the top.  You are now assembling your 3' to 5' chain as shown above in the diagram.
DNA back bone double helix molecular model kit
























When done you should have a structure that resembles the following model below (DNA-1000 demonstrated).
DNA double helix molecular model

 

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